Sentence examples for binding of the variant from inspiring English sources

Structural differences between Variant FS and wild type are also reflected in the loss of binding of the variant to FcγRII and FcγRIII receptors.

Expression of these variants causes distinct changes in regulation of cell differentiation and survival as a consequence of differences in GTP binding of the variant proteins (Antonyak et al. 2006; Tee et al. 2010).

The decreased silencing activity of 5'-isomiR-101 5'-isomiR-101 5'-isomiR-101ding of this vagrees to Ago2 complexes.

Therefore, the W361F variant was selected for further investigations of its biochemical properties and the conversion of ginsenoside Rb1 to compound K. Homology modeling of the W361F variant SS-BGL was performed based on the crystal structure and binding energy of the variant enzyme was compared with that of wild-type enzyme.

The binding energy (∆E binding) of the W361F variant enzyme docked with Rd (− 183.2 kcal mol−1) was lower than that with the wild-type enzyme (− 59.7 kcal mol−1).

In the 1H-15N Hspectracomparedmpared with that of free PHD1KDM5B, the binding to wild-type H3A1 (i.e., H3K4me0) produces a large shift in most of the cross-peaks of PHD1KDM5B, whereas the binding of the H3G1 variant does not induce this shift.

Our GST-pulldown assays clearly demonstrate impaired binding of the DSC2a A897fsX900 variant to PG and DSP, while binding to PKP2 was virtually unaffected.

This effect is partially offset by the increased level of binding of the E46K variant, but nevertheless, cross-peaks are somewhat weaker for this mutant relative to WT and also relative to the A53T variant.

Specificity of binding of the A3 variant was evaluated by a cross-reaction panel to various toxins and proteins (see above list) coupled to microspheres via a direct binding assay.

At the same time, the ssDNA-binding affinities of the variant HsmtSSBs are unaffected over the range of 20 100 mM KCl (Fig. 4 and data not shown).

Such a situation in which a key GDP/GTP contact residue is perturbed could lie behind the differential guanine binding of the two variants.