Sentence examples for binding of the tracers from inspiring English sources
Degree of D2/3R-specific binding of the tracers was characterized by BPND (as given above) or the specific binding ratio (SBR) given as target region activity/cerebellar activity - 1.
Plasma protein binding of the tracers was determined using an analytical Chiralpak human serum albumin (HSA) column (50 × 3 mm, 5 μm) according to a previously published protocol with minor changes [16].
In addition, the non-blocking of the competing drugs observed in the tumour in the present study could also be due to a number of variants such as the non-specific binding of the tracers in the tumour, internalisation or internal localisation of surface receptor-ligand complex in the tumour that was not readily blocked by the competing σ ligands when the radiotracers were administered.
Indeed, in our current study, the specific binding of the tracers in mice was evaluated at the time of highest brain uptake under the baseline condition.
Interestingly, no significant significant difference in BPND between the two tracers was found in the control rats, which seems to indicate that nonspecific binding of the tracers under physiological conditions is similar.
Two mechanisms were assessed: binding of the tracer to melanin or to sigma receptors of melanoma cells.
The autoradiograms presented binding of the tracer to the tumor sections.
Non-specific binding of the tracer in the tissue can slow down the association rate of the tracer-receptor binding by leaving less free tracer in the tissue.
Relatively low receptor affinity could lead to low binding potential, which results from substantial binding of the tracer to other parts of the body.
Pretreatment of the tumor sections with ALK5 blocking agents EW-71977, SB-431542 and the ALK5 inhibitor) decreased the binding of the tracer significantly.
A prediction of the target-bound fraction of tracer (ftb) was made from measurements of target affinity, density, and the non-specific binding of the tracer measured in brain slices.
