Sentence examples for binding of the target from inspiring English sources

FKBP39, a Drosophila homolog, can bind the immunosuppressive drug FK506 and mediate the binding of the target element of JH and showed a dynamic upregulation from 3 hpi to 24 hpi [76].

The mismatch probe differs from the perfect match probe by a single base substitution at the center base position, disturbing the binding of the target gene transcript.

Molecularly imprinted polymers (MIPs) have been developed mostly for the specific binding of the target, mimicking the function of antibodies.

The oriented binding of the target protein to the SAM during formation of the MIP generates uniform binding sites.

Thus, specific binding of the target protein of interest should be enabled even in complex solutions such as e.g., biotechnologically relevant cell lysates.

Among them, tartaric acid derivative (5) exhibited the most effective reduction of nonspecific binding proteins, whilst maintaining binding of the target protein.

This observation is consistent with the binding of the targeting ligand to shed or soluble EGFR, to smooth muscle cells in the blood vessels and/or tracer dissociating from EGFR receptors and returning to the circulation [16].

Covalent binding of the targeting ligands to the liposome is achieved by coupling to lipids with a functional reactive group, such as maleimide, thiol, amine, or carboxylic acid.

Therefore, specificity of target recognition is of pivotal importance because strong binding to an off-target site, resulting from binding of the targeting device, could also lead to a stable, but unwanted epigenome modification around that region.

Highly selective bindings of the target species have been observed against competing species of similar sizes and shapes.

These algorithms rank compounds by modeling the binding pose of a query molecule in the binding pocket of the target protein, followed by the prediction of binding affinity from molecular interactions.