Sentence examples for binding of the substrates from inspiring English sources
These data indicate that numerous mutations distal from the active site contribute to enhanced 'uniform binding' of the substrates, which is the first step in the evolution of novel catalytic activity.
The first step is recognition and binding of the substrates by the recombinase [23].
Taken together, these results suggest that the binding of the substrates and/or the formation of the intermediate, biotinyl-5'AMP, protects BPL from protease cleavage.
In the absence of substrates, cMyco or Fe-cMyco, there was no change in the intrinsic fluorescence quenching of the two proteins over a period of time (Fig. 5A and B, green curve) indicating that the quenching is indeed due to selective binding of the substrates to the proteins.
The complete assay mixture without the plant extract served as the control to monitor non-specific binding of the substrates.
In these cases, it is unnecessary to co-annotate the binding of the substrates, cofactors or products, as the enzymatic activity is defined by the compounds being bound, if only in a transition state.
Other molecules act as activators; i.e., they interact with an enzyme so as to enhance the binding of the substrate to the enzyme, thus enhancing catalytic activity.
In the latter, the inhibitor does not prevent binding of the substrate to the enzyme but sufficiently changes the shape of the site at which catalytic activity occurs so as to prevent it.
These data have shown the great diversity of sizes, shapes, and modes of binding of the substrate binding sites of these mammalian cytochromes P450.
The distal carbonyl group of TAC protrudes into the fatty acid binding channel of MtbHadAB, occluding the binding of the substrate (Fig. 6C).
