Sentence examples for binding of the substrate from inspiring English sources

The product molecule may bind directly at the active site, blocking further binding of the substrate molecule, or it can bind at the proximity of the active site and influence structural constraints for substrate binding.

The significance of this finding for the development of new anti-TB drugs can be surmised from the structural observation that flavonoids and possibly TAC and ISO bind in this pocket, which disrupts binding of the substrate.

mixed inhibitor binds to an allosteric site and the binding of the substrate and the inhibitor affect each other.

These findings suggest that the binding of the substrate to the catalytic domain is impaired in the absence of PHD1.

When riboswitches were first discovered, two questions immediately arose: how is the metabolite recognized, and how does binding of the substrate trigger genetic regulation?

Its activity is tightly regulated by the binding of the substrate PRFAR to its partner synthase domain.

In the latter, the inhibitor does not prevent binding of the substrate to the enzyme but sufficiently changes the shape of the site at which catalytic activity occurs so as to prevent it.

Here we show that saturation of the PHD1 domain by the H3 N-terminal tail peptides stabilizes binding of the substrate to the catalytic domain and improves the catalytic efficiency of demethylation.

Since L418A mutation site is structurally far from the active site, it cannot influence the binding of the substrate directly.

Other molecules act as activators; i.e., they interact with an enzyme so as to enhance the binding of the substrate to the enzyme, thus enhancing catalytic activity.

These data have shown the great diversity of sizes, shapes, and modes of binding of the substrate binding sites of these mammalian cytochromes P450.