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Cell staining by this control sequence was ~1.5-fold over that of unstained cells, indicating minor non-specific binding of the small RNA that was not evident for the large RNA payload.
Similar to the ZipA/FtsZ contacts, the driving force in the binding of the small molecule ligands to ZipA is achieved through hydrophobic interactions.
The proteolysis of the toxin is mediated by a conserved internal Cys protease domain (CPD), which is activated upon the binding of the small molecule inositol polyphosphate (IP6).
As temperature increases, the hairpin structure can 'melt' and expose the RBS or Shine-Dalgarno sequence to permit binding of the small ribosomal subunit (30S), which then assembles other translation machinery.
During the injection of melittin this mass change is attributed to the binding of the small peptide to the lipid vesicles.
TTR related amyloidogenesis lacks an effective therapy, although it has been observed [21] that amyloid fibril formation is prevented by the binding of the small molecule T4.
Similar(41)
Because of the binding of HIV-1 to contaminating leukocytes (Fig. 3A), the question arose whether the apparent binding of HIV-1 to non-hemolyzed cells actually consisted of binding to the small number of contaminating CD4 cells.
This supports the conjecture that their in vivo biological activity might result from binding of the small-molecule with the intended target protein.
The binding of the small-molecule CXCR4 antagonist AMD3100 to CD4/CXCR4-proteoliposomes was analyzed by FACS using a competition assay [47], [55].
At this stage we are not sure about the functional significance of the binding of these smaller polypeptides to the mIRF2; however it is tempting to speculate that these proteins might negatively influence the translation initiation in the mIRF2 RNA.
In particular, we demonstrated that the H-bond interaction between calcipotriol and Ser237 played a major role in the binding abilities of the small molecule ligand, as shown by the high conservation ratio through the MD simulation.
More suggestions(17)
binding of the minor
intertwining of the small
binding of the minimal
binding of the reduced
binding of the radiolabelled
binding of the second
binding of the active
binding of the anti-AT1R
binding of the fourth
binding of the targeted
binding of the immunoconjugate
binding of the secondary
binding of the polyclonal
binding of the hybrid
binding of the former
binding of the different
binding of the same
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