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Gene product imaging can be accomplished by measuring the accumulation or binding of the respective radiolabeled substrates or ligands.
Note that the mismatched pairing noticeably reduces specific binding of the respective target to the MM probes compared with the respective PM-probe.
However, blockade of ILT4 by antibodies did not fully abrogate binding of the respective tetramers/pentamers to monocytes, suggesting that interactions with alternative MHC class I receptors on myelomonocytic cells might contribute to the recognition of these tetramers/pentamers.
Both peptides (15/3/6: ligand to VT80.12; 43.12p3: ligand to VF1-TP43) inhibindinginding of the respective mAb to the HMW-MAA up to 100%, thereby proofing epitope mimicry and their definition as mimotopes.
Here, we show that mutational escape in three HLA-A11-, B8- and B7- restricted immunodominant HIV-1 CTL epitopes consistently enhances binding of the respective peptide/MHC class I complex to Immunoglobulin-like transcript 4 (ILT4), an inhibitory myelomonocytic MHC class I receptor expressed on monocytes and dendritic cells.
We observed that a major naturally occurring escape variant with an amino acid substitution at position 5 (K5E) in the epitopic peptide substantially increased binding of the respective tetramer to CD14+ monocytes as compared to the tetramer refolded with the wild type tetramer (Figure 1).
Similar(37)
Consequently these are constitutional principles, binding on the respective partners and of very great importance for the construction and integration of Community institutions.
The MS/MS spectrum at the bottom left of Fig. 5a shows the four characteristic iTRAQ reporter signals indicative of the relative amount of protein kinase trapped and thus of the percentage of ligand binding to the respective protein kinase.
Phosphorylated receptor-regulated SMADs form complexes with SMAD4 that translocate to the nucleus where they regulate the transcription of a wide variety of target genes by binding to the respective promoter elements of these genes (Ross and Hill, 2008).
We are interested in the control aspect: some proteins, called Transcription Factors, possess the ability to regulate the expression of genes by binding to the respective promoter regions on the DNA and thereby influencing their transcription processes.
Such target depletion effectively reduces the binding affinity of the respective probes for specific binding [ 37].
More suggestions(14)
binding of the various
binding of the two
binding of the radiolabelled
binding of the second
binding of the active
binding of the targeted
binding of the immunoconjugate
binding of the polyclonal
binding of the secondary
binding of the former
binding of the hybrid
binding of the different
binding of the same
binding of the non
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