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Binding of positively charged SAM molecules is believed to promote binding of the repressor to its target DNA by a unique mechanism based primarily on long-range electrostatics transferred through the protein structure.
The binding of the repressor protein to the tetO1 shuts down the expression of both the two genes.
We consider the binding of the repressor, nuclear Mig1p, and Gal4p, to the respective binding sites as reversible stochastic reactions.
To explain this, a differential cooperativity model was proposed, in which there is self-cooperative binding of the repressor but not activator isoform of Ci.
In the repressor configuration, regulation is mediated by the binding of the repressor (CymR) to the operator site (CuO), placed downstream of a strong constitutive promoter.
In the second and more frequent class, the metabolite effector is an intermediate metabolite of the pathway like, for example the PRPP, which induces purine biosynthesis by preventing the binding of the repressor PurR to DNA [ 62].
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Note that we observed expression decreases at higher concentrations of Pgal, which can be explained by the competitive binding of Pgal to the inducer binding site of the repressor (see Additional file 1).
CIRCE is a highly conserved DNA sequence that serves as binding site of the repressor protein HrcA.
The importance of this feature is investigated through a set of simulations in which the binding strength of the repressor for the operators is 10, 50 and 100 times lower than the wild type value.
The binding of the putative repressor to the q allele is CpG methylation-dependent (van Laere et al, 2003).
It was further shown that methylation of H3R8 slightly reduces the binding of the transcriptional repressor HP1α to H3K9me3.
More suggestions(16)
binding of the buffer
binding of the myosin
binding of the p57T143A
binding of the peptide
binding of the fusion
binding of the radiolabel
binding of the heterodimer
binding of the target
binding of the ligand
binding of the hormone
binding of the action
binding of the karma
binding of the initiator
binding of the nation
binding of the protein
binding of the rabbit
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