Sentence examples for binding of the regulatory from inspiring English sources

We propose a multi-step activation mechanism in which the sequential and cooperative binding of the regulatory domains to the membrane is coupled to allosteric activation of the kinase domain by DAG and that acquisition of full catalytic activity requires DAG binding to the C1B domain.

We observed only a minor amount of binding of the regulatory R1 domain of PKA to HSF1 (Fig. 1).

The regulation of the genes in first category requires, in addition to HU, specific DNA binding of the regulatory proteins LexA, GadX or FNR.

To check this hypothesis we first analyzed if the binding of the regulatory proteins H-NS, StpA, LRP and FIS to the rsd promoters was affected by DNA methylation.

PKA activity is suppressed by binding of the regulatory subunits (PKA-R) to the catalytic subunit, and overexpression of PKA-R decreases, while knockdown of PKA-R increases, PKA activity.

The intrinsic flexibility of the A scaffolding subunit [14] as well as the AC core dimer, which experiences profound conformational rearrangements after binding of the regulatory subunit [15], [16], has been proposed to be important for binding different regulatory subunits and for performing catalysis on a wide variety of substrates.

The AKAP13 gene encodes the A-kinase anchor protein 13 that has the function of binding to the regulatory subunits of PKA (Supplementary Figure 4).

The consequence of calcium binding to the regulatory domain of APC is a stimulation of the substrate transport activity of the carrier [2,4,7].

An A-kinase anchor proteins (AKAP) have the function of binding to the regulatory subunits (RI and RII) of protein kinase A (PKA) and confining the enzyme to discrete locations within the cell.

Thus, Lola may directly modulate the transcription level of GluRs by binding to the regulatory region of the genes.

We have previously demonstrated the existence of an interaction between Reelin and Lis1 signaling consisting of the direct binding of Lis1, the regulatory subunit of the Pafah1b complex, to the adapter Dab1 [23].