Sentence examples for binding of the parental from inspiring English sources
Such "PIN-bodies" were able to bind CD4 with a better affinity and specificity than the soluble PDP; additionally, in competitive ELISA experiments, CD4-specific PIN-bodies were more potent inhibitors of the binding of the parental recombinant antibody 13B8.2 to CD4 than the soluble PDP.
Controls included binding of the parental (Opa-) strain on wild type neutrophils and Opa52-expressing bacteria binding to human neutrophils.
Tumour binding of the parental antibody CEA6 consistently gives the highest tumour-blood ratios at 24 h (mean 16:16.
Kinetic parameters for binding of the parental and of five affinity matured variants to sIL-6R were determined via SPR.
We here demonstrate that the conservative replacement of Asp-Thr within the sequence PDTRPAP by Glu-Ser has a severe negative impact on the binding of both, the parental antibody C595 and the scFv-Fc-IL2 fusion protein, which indicates a contribution of these two residues to the epitope structure of the C595 antibody.
The similar KD values in h357 and m357 IgGs indicated that the humanization process did not alter the TNF-α binding strength of the parental mouse antibody.
Single-chain variable fragments (scFvs) are the smallest functional fragments of immunoglobulins that maintain the antigen-binding specificity of the parental molecule.
As shown in Figure 4, the binding patterns of the fusion proteins to the panel of MUC1-derived antigens are similar to that of the monoclonal antibody C595 indicating that the C595 scFv domain in the fusion proteins conserved the antigen-binding profile of the parental C595 mAb.
All of the monovalent and multivalent MSH4 constructs exhibited binding comparable to that of the parental ligand, suggesting that either the ligand spacing was inappropriate for multivalent binding, or MSH4 is too weak a binder for a second 'anchoring' binding event to occur before the monovalently-bound construct is released from the cell surface.
As immunogens inoculated into guinea pigs, the 2F5 ES proteins elicited antibodies with exquisite binding specificity matching that of the parental 2F5 antibody [41].
As shown in Figure 2B, scFv G28-5 fused with the E-E34, R-R34 and EE12RR345L zipper domains exhibited levels of binding comparable to the parental G28-5 mAb.
