Sentence examples for binding of the parent from inspiring English sources
From fluorescence and absorbance studies it was inferred that all the analogs bound to DNA non-cooperatively in contrast to the cooperative binding of the parent alkaloid berberine.
We propose that covalent binding of the parent drug can contribute to INH-induced hepatotoxicity and autoimmunity.
The synthetic peptide also competed and inhibited in vivo the binding of the parent phage to the cognate synovial MVE ligand.
The effects of BPA exposure on Muc5B may be due to the binding of the parent molecule or its metabolites to estrogen receptors (Okuda et al. 2011).
The N,O-sulfonates are highly labile metabolites that generate reactive intermediates involved in the covalent binding of the parent compound to protein, RNA and DNA, as well as to low molecular compounds like glutathione.
The pharmacological interaction of drugs with immune receptors (PI) concept is a relatively new theory (Fig. 43) which does not rely on covalent binding of peptides to MHC molecules to stimulate the immune response, but rather a non-covalent direct binding of the parent drug to the T-cell receptor or MHC triggering a response (Pichler et al. 2006).
Binding of an 19F-labeled eremomycin analog in the FemA cell wall matches that of binding to the parent-strain cell wall and reveals the proximity of parallel stems in the alternating parallel perpendicular mixed-geometry model for the FemA peptidoglycan lattice.
The results suggest that cLac effectively mimics the membrane binding mechanism of the parent protein lactadherin.
In contrast, the binding potencies of the parent drug and of all its macromolecular derivatives for the antibody were within the same order of magnitude.
The early vital information on the biotransformation of insulin glargine (11) was seemingly ignored for many years, with research groups having chosen instead to focus on the in vitro IGF-1 binding properties of the parent compound insulin glargine.
