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Binding of a ligand has an influence on binding of the other ligand and vice versa.
The fourth substituent seems to disturb the binding of the other three substituents, so the activity is reduced as compared to tri-substituted benzene and pyridine derivatives.
Hence, the affinity towards another Gb3 molecule on the membrane should be higher compared to free PNPG, since the dissociation of one ligand should not change the orientation towards the membrane introduced by the binding of the other three ligands.
Analysis of the MD trajectories for the two complexes reveals interesting features which may explain the stability of the complex obtained for the first molecule versus the poor binding of the other ligand.
The binding of Na+2 is coupled to binding of the other two sodium ions and aspartate by the positioning of M314 at the center of the triangle formed by aspartate, Na+1 and Na+2 (Fig. 4b), and by the conformation of the tip of HP2, which interacts both with aspartate and with Na+2.
In contrast, the binding of the other anti-MCP sera to RCM gp120 is not significantly affected (Table 2).
Similar(20)
The results also showed that deficiencies in SSI, BEI and BEIIb affected the starch granule-binding of the other isozymes.
It appears that the binding of each HAT correlates with the binding of all the other HATs tested.
Interestingly, the individual mutants also reduce the binding of the correspondingly other molecular chaperone to the other TPR domain to some extent (Fig. 5C).
Side chains of several residues (101 110) from the structural zinc binding loop of the catalytic domain of one subunit also interact with residues (260 262) of the coenzyme binding domain of the other subunit in a dimer.
We also describe the use of molecular docking studies to explore the binding interactions of the other 5 related HDACi.
More suggestions(17)
obligations of the other
binding of the alternative
settings of the other
impediments of the other
binding of the radiolabelled
binding of the anti-AT1R
binding of the active
binding of the fourth
binding of the targeted
binding of the immunoconjugate
binding of the polyclonal
binding of the secondary
binding of the former
binding of the hybrid
binding of the same
binding of the non
binding of the mutant
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