Sentence examples for binding of the origin from inspiring English sources

The process is initiated by the binding of the origin recognition complex (ORC) to replication origins, followed by assembly of a pre-replication complex (preRC), which includes Cdc6, Cdt1, and the MCM complex (Dutta and Bell, 1997; Li and Stillman, 2012).

We show that DS is the most active origin of replication present in the mini-EBV genome regardless of its location, and it is characterized by the binding of the origin recognition complex (ORC) allowing subsequent replication initiation.

A kinetic mechanism of RepD initiation is presented, showing rapid binding of the origin DNA.

One of the key steps in determining sites of replication origins is the binding of the origin recognition complex (ORC).

The initial step in origin licensing is the binding of the origin recognition complex (ORC) to chromatin.

This was interpreted as suggesting that centromere formation facilitated binding of the origin recognition complex (ORC) to centromere loci (Koren et al., 2010).

They do not seem to be dependent on replication initiation either since only 20% of them colocalize with sites of binding for the Origin Recognition Complex (ORC) [ 6].

Using the DNA binding domain of the origin binding and transcriptional regulator protein E2 from human papillomavirus type 16 as model, and through isothermal titration calorimetry analysis, we determined a positive, entropy-driven cooperativity upon binding of the protein to its cognate tandem double E2 site.

On this basis, we propose that the primary determinant of E2F binding to the origin regions might not be primary DNA sequence recognition by E2F itself, but its interaction with chromatin-bound Rb, consistent with the information that chromatin-bound Rb is also detected during the S-phase [36].

The relaxase initiates conjugation by binding to the origin of transfer (oriT), a process which is facilitated by MobC.

Of interest, Orc1 binding to the origin was not detectable in G0, despite the protein being expressed; in early G1, the protein started to associate with the origin and its enrichment peaked in mid G1 (4–5 fold).