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The binding of the organic molecules to the receptor was evaluated on the basis of the interaction energy (Coulomb and van der Waals interactions) between receptor and ligand or cofactor peptide.
The binding of the organic co-substrate α-KG co-substrate dependent facial triad enzymes (e.g. CS2) in general do not lead to a loss of water and it has been argued that there, the facial triad's prototypical carboxylate ligand stabilizes the 6th water ligand via its non-coordinated oxygen.
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The RKIP-PE complex is the only crystal-based structural evidence to date for the binding of an organic ion to the pocket.
This was explained by the chelating characteristics of organic acids and by the binding of Pb to organic acids and enzymes, which kept the Pb dissolved in the intestinal fluid and prevented precipitation.
In this context, the direct binding of functional organic conjugated molecules (stilbene derivative) onto the surface of monodisperse Fe3O4 magnetic nanoparticles has been studied.
Further, we examined the PPARγ binding of semivolatile organic compounds that are structurally similar to known PPARγ agonists, such as organotins and halogenated bisphenols.
It will be further improved by the characterisation of the organic binding media employed in the paint tubes in the frame of a JPI European project dealing with the study of modern oils in painting materials [37].
Detailed density functional theory (DFT) simulations of the SAM NO2 binding interactions and subsequent changes of the organic surface group frontier molecular orbitals indicate that the nature of the chemical SAM structure directly determines the gas response of the hybrid material (Fig. 5e).
However, these serum mineralo-protein complexes are formed from the direct chemical binding of inorganic and organic phases, bypassing the need for any biological processes, including the long cultivation in cell culture conditions deemed necessary for the demonstration of NB.
The fact that Arg-201 is fully conserved in the SLC17 family implies that this residue may be important for binding of both organic and inorganic anionic substrates.
Given a (calculated) log Kow of 2.5, the unspecific binding of the uncharged tylosin molecule to organic carbon should be moderate [22].
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