However, HSF1 is activated through a complex mechanism, which involves release of a negative regulatory domain, leucine zipper 4 (LZ4), from a masked oligomerization domain (LZ1-3), and subsequent binding of the oligomer to heat shock elements (HSEs) in HSF1-responsive genes.
DOI: http://dx.doi.org/10.7554/eLife.04120.013 Previous crystal structures of Rev dimers and the NMR structure of a Rev ARM-IIB complex defined key building blocks of Rev-RRE assembly, but it has been unclear how they are employed to guide cooperative RNA binding of the oligomer to assemble a fully functional complex.
In this model, a pre-pore oligomer structure is formed after Cry1Ab interaction with cadherin, and binding of this oligomer to APN and ALP is necessary for its membrane insertion in midgut epithelium cells.
However, binding of the PT B oligomer (PTB) to cell surface molecules can elicit several intracellular signaling events independent of the enzymatic activity of the toxin A subunit [53].
Wurzer, Zaffagnini et al. observed that the binding of p62 oligomers to ATG8 proteins and damaged structures with ubiquitin tags, drive the bending of the membrane around these structures.
Therefore, the observed higher stoichiometry is not due to the binding of higher-order oligomers of the protein present in solution.
During the binding of oligomers to Lamp2a, the receptor is not allowed to bind to any other entities (other Lamp2a substrates).
Moreover, data obtained from acute murine hippocampal slices indicate that synaptic Zn2+ facilitates the binding of A β oligomers to the GluN2B subunit of the NMDAR in MF terminals and interferes with glutamatergic transmission.
Because self-association of apoE is ruled out under our experimental conditions, the presence of clusters of apoE molecules indicates binding of apoE with the oligomers and/or protofilaments of Aβ1 42 in this phase.
