Sentence examples for binding of the nuclear from inspiring English sources

This serine lies directly within the cyclin B1 nuclear export sequence and, when phosphorylated, prevents binding of the nuclear export factor, CRM1.

Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1. Activation of the Cyclin B/Cdc2 kinase complex triggers entry into mitosis in all eukaryotic cells.

EMSA revealed the specific binding of the nuclear extract from C/EBPβ-overexpressed ATDC5 cells with the oligonucleotide probe containing the identified responsive element above (Figure 5D).

We then transfected Gsk-3β+/+ and Gsk-3β+/– osteoblasts with Runx2, and compared the binding of the nuclear extracts with the oligonucleotide probe of the Runx2 binding sequence, osteoblast-specific cis-acting element 2 (ofE2) of the mouse osteocalcin gene promoter [18], by electrophoretic mobility shift assay (EMSA).

Finally, this product also inhibited the sequence specific binding of the nuclear factor AP1 to HPV18-LCR.

These results indicate that this band was formed by specific binding of the nuclear protein in the brain.

The -1377G/A is situated at the transcription factor SP-1 binding site [ 22], and the -670A/G substitution is located in the enhancer region and abolishes the binding site of the nuclear transcription element GAS (Gamma Interferon Activation Sequence).

A high-throughput screen of the ligand binding domain of the nuclear receptor retinoic acid-related orphan receptor gamma t (RORγt) employing a thermal shift assay yielded a quinoline tertiary alcohol hit.

To address the question of ligand entry process, we report targeted molecular dynamics simulations of the entry of the flexible ionic ligand GW0072 in the ligand binding domain of the nuclear receptor PPARγ.

In general, this switch is mediated through a conformational change in the ligand binding pocket of the nuclear receptor leading to dissociation of co-repressors and interaction with co-activators.

In contrast, a slight increase in the DNA binding activity of the nuclear proteins was observed when A-172/m p53/248 cells were treated with heat (44°C, 30 min) (Fig. 3, the lower column, lanes 3).