Suggestions(1)
Exact(5)
Comparisons between the crystal structures of the binary (RTP/T) [1], [5], [9] and ternary complexes (+1 dNTPRTP/T)[4], [10] show that binding of the next complementary dNTP results in a conformational change in which the enzyme closes in on the P/T and the "fingers" subdomain moves closer to the downstream (single-stranded) portion of the template.
In order to start a new elongation cycle, the A site must be emptied to allow binding of the next aminoacyl-tRNA.
EF2 is responsible for the translocation of the peptidyl-tRNA from the acceptor site to the peptidyl-tRNA site of the ribosome, thereby freeing the A-site for the binding of the next aminoacyl-tRNA.
With a rate of 20 codons/s for protein elongation (27) and the need to clear the occluded ribosome binding site (1) to allow for the binding of the next ribosome, the lower limit for the initiation rate is about 0.3 s-1.
Binding of the next ATP at 240°, filling the third catalytic site, initiates further rotation beyond 240°, which promotes the release of ADP.
Similar(54)
In eukaryotes, all ubiquitin-associated pathways are characterized by a crescent complexity, since more E2s than E1s, and more E3s than E2s exist; therefore, the number of proteins potentially involved in each step increases, as well as the specificity of binding to the next substrate [ 72].
Communication between the heads ensures that binding, release and finding of the next binding site for each head leads to movement.
7a There remains some controversy about the order of steps between phosphodiester bond synthesis and stable NTP-Mg2+ binding for formation of the next bond.
To further refine the limits of the binding pocket, the next residue whose effect we tested along the ECD helix was I52.
"It is so frail and delicate at night that she can't even imagine the next morning, but it is so wide and binding by the middle of the next day that she cannot even remember the terrible night.
Multiple functions of tankyrases in accordance with a variety of binding partners pose the next challenging question about potential side effects of tankyrase-directed cancer therapy.
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