Sentence examples for binding of the natural from inspiring English sources

Although the ligand binding site can be at the VFTM dimeric interface [9], [36], usually ligands bind into the VFTM binding pocket and in Class-C GPCRs binding of the natural ligands induces closure of the VFT responsible for receptor activation [12].

We conclude that AMD3100 binds efficiently to CXCR4 on the CD4/CXCR4-proteoliposomes. We examined the binding of the natural CXCR4 ligand, CXCL12 [15], [58], [59], [59], to CD4/CXCR4-proteoliposomes. The shorter, 68-residue α isoform [60] of CXCL12 was used for these studies.

Ability of this mimic to inhibit the binding of the natural Glc1Man9GlcNAc oligoside to calnexin has been measured.

The rational design preserved binding of the natural substrates to the G protein, and the mutations were functionally innocuous in a cellular context.

Toward that end, we have evaluated the binding of the natural product to its target protein computationally and formulated a class of simplified analogs based on the structural analysis.

KYK-2.0 Fab blocked the binding of the natural human NKG2D ligands MICA, MICB, and ULBP2 as potently as a commercially available mouse anti-human NKG2D monoclonal antibody in immunoglobulin G (IgG) format.

The presumed function of these agonist drugs is through their binding to the natural cellular receptors of GABA within the neurons of the central nervous system that are located either in the spinal cord or within the brain tissue.

These results identified at least one Pax6-binding site from major ChIP-on-chip "peaks" and showed that the binding affinities of the natural Pax6-binding sites were lower compared to the P6CON.

While conventional CD28 mAbs bind CD28 close to the binding site of the natural CD28 ligands, CD80 and CD86, CD28 superagonists bind to a laterally exposed loop within the extracellular domain of CD28 [8].

We identified a 7 AA-long deletion near the binding site of the natural ligand 9-cis-retinoic acid in the ligand-binding domain (LBD) of RXR-α.

The inhibition of IgE-binding to the natural allergen observed after pre-incubation of the 20 sera with rabbit anti-SlpB-AH3a42 IgG was more than 30% for four sera, more than 20% for eight sera, and below 10% for eight sera.