Sentence examples for binding of the native from inspiring English sources

It was observed that the binding of the inhibitor 2-aminoperimidine established interactions different from those introduced by the binding of the native ligand.

Reciprocal Cys<->Ser mutations at residue 67 of the native Nv-NF-κB proteins affect DNA binding as in human NF-κB proteins, e.g., a Cys->Ser mutation increases DNA binding of the native Cys variant.

This specificity of erythrocyte binding of the native PfRH2a/b is consistent with a previous knockout study, which on the basis of differences in the invasion phenotypes between the PfRH2b knock out and wild type parasite lines, had demonstrated PfRH2b to play a role in a sialic acid independent, trypsin resistant, chymotrypsin sensitive invasion pathway [16].

It is a negatively charged deep groove formed by such amino acids like Asp189, Ser195, and Tyr228 that serves for binding of the native substrate arginine.

To determine how the V41Y and A134F variants were able to discriminate against the binding of the native fatty acid ligands, we generated crystal structures of both V41Y and A134F in the presence of hexanoic acid.

Unlike binding of the native ligands that allow receptor recycling, several laboratories have shown that monoclonal antibody binding results in endosomal degradation of the receptor (Sachdev et al, 2003; Wang et al, 2005).

Recently, Sun et al. (2016) designed an immunogen containing four tandem 10E8 epitope repeats that exhibits α-helical conformation and the key amino acids W and F, which can point toward different directions when the long peptide binds the plasma membrane, thereby strengthening the induction of antibodies capable of binding to the native conformation of MPER on the viral envelope.

In addition, the absence of compounds showing high affinity for TTR but low inhibition potency indicate that the fibrillogenesis inhibition properties of these diflunisal analogues arise because of selective binding to the native state of the protein and subsequent kinetic stabilization of its tetrameric form.

Metal-mediated stability is the consequence of differential binding to the native and unfolded states.

Cofactors can aid protein stability, of course, through preferential binding to the native state [ 33, 34].

This receptor has higher affinity for binding to β-arrestins while retaining the ligand binding properties of the native β2AR.