Sentence examples for binding of the most from inspiring English sources

Subsequently, the binding of the most active compound to the DNA gyraseB enzyme and its thermal stability was further characterized using differential scanning fluorimetry method.

In silico docking suggests a unique mode of binding of the most efficient compounds to the β1 catalytic site (PA activity) in relation to the chemical nature of C1 substituents.

Docking studies were also performed to compare the binding of the most potent and least potent compounds in the study in order to predict desirable chemical characteristics for further exploitation in drug design efforts.

Subsequent analysis, including site-directed mutagenesis studies, showed that two specificity clusters exist in each of the investigated PDZomes, and that the presence of a histidine and valine residue in alpha-helix 2 (residues αB1 and αB5, respectively) determines the binding of the most promiscuous cluster.

We set about to examine the binding of the most promising analogs more closely via molecular docking.

In addition, it was recently shown that efficient binding of the most conventionally used amyloid ligand, Congo Red, to amyloid fibrils is highly dependent on electrostatic interactions and hydrogen bonding.

On the other hand, Figure 6A illustrates that the binding energy of the most energetically favorable binding mode of compound 4b towards the active site of BuChE is -8.90 kcal/ mol, consistent with the results of enzyme inhibition assay that compound 4b is more active to BuChE than to AChE.

The methylation study was focused on CpG-sites whose methylated states may affect the binding of SREBF1, the most relevant transcription factor of ELOVL6.

Mutations Gly2185.42Ala/Ser impacted the binding of -crebanine the most, causing the Tm values decreased over 6.0 °C and ligand-binding capacity reduced by over 60%.

Again, the binding energies of the most stable conformer of 3 are identical to those from the solution binding studies.

The binding of prometryn (the most hydrophobic analyte in the study) is significantly suppressed because in toluene the retention mechanism is driven by normal-phase behavior, i.e., the more polar molecules are preferentially bound to the polymer.