Sentence examples for binding of the minor from inspiring English sources

The constitutive SrtA catalyzes the covalent binding of the minor ancillary AP2 to peptidoglycan and since its inactivation leads to pilus secretion [28], the 515 ΔsrtA mutant is incapable of forming biofilms according to data obtained in GBS NEM316 ΔsrtA mutant strain (Figure 6B and [9]).

The results of our microarray experiments and associated sequence analysis provide insight into the sequence patterns required for binding of the minor groove binder berenil in the environment of yeast cells.

Its mechanism of action is linked to binding to the minor groove of DNA and to a variety of modulatory effects on the tumor microenvironment, including changes in the production of several inflammatory mediators like the chemokines CCL2 and CXCL8, the cytokine IL-6 and the angiogenic factor VEGF [ 13].

Trabectedin consists of three fused tetrahydroisoquinoline rings referred to as subunits A, B, and C. Experimental data strongly suggest that the cytotoxic effects of trabectedin depend on its binding to the minor groove of DNA at the N2 position of guanine with some sequence specificity [23].

Driven by the process of the helix α4 binding to the minor groove of the DNA, the helix α3 reorients itself moving into the major groove of the DNA bringing the 100-122 loop closer to the same groove.

A series of head to head linked dimers of heterocyclic amino acids has been prepared for investigation of affinity and selectivity in binding to the minor groove of DNA.

Pyrrole-imidazole polyamide (PIP) is a nuclease-resistant novel compound that inhibits gene expression through binding to the minor groove of DNA.

The Lamarckian genetic algorithm (AutoDock 3.0) was used to model the interaction/binding between m-iodo-p-methoxyHoechst (IMH), a ligand available in the Protein Data Bank whose binding to the minor groove of DNA has been demonstrated (crystal structure), and the oligonucleotide d CGCGAATTCGCG 2.

Second, tau protein is demonstrated binding to the minor groove of dsDNA without nucleotide sequence specificity (Figures 4 6).

One early concern was that the inhibitors might block polymerases non-specifically, by binding to the minor groove of the nucleic acid substrate.

HMGA1 contains AT-hook domains allowing its binding to the minor groove of AT-rich sequences; high affinity actually requires multiple properly phased AT-tracts [52] with spacing <10 bp.