The increase in the major groove width with the increased DNA content is the reason for the gradual decrease of TRBP-RBD2 binding to the major groove of the three duplexes.
In our results, the second α-helix of the HTH contributes most of the DNA recognition, binding to the major grooves of the DR-DNA, and interacting mostly with the DNA bases.
EIs are 6.5-fold enriched for DNase I Hypersensitive Sites and 8-fold enriched for the binding of CTCF, the major organizer of higher-order chromatin.
The classical Early Growth Factor (EGR) gene, zif268 (Fig. 1) shows the main recognition motif, a helix binding to the major groove of the DNA.
We have constructed and clinically evaluated a hypoallergenic vaccine for grass pollen allergy, BM32, which is based on fusion proteins consisting of peptides from the IgE binding sites of the major grass pollen allergens fused to preS (preS1 + preS2), a domain of the hepatitis B virus (HBV) large envelope protein which mediates the viral attachment and entry.
And, based on the existing research results, future studies are worthy to be performed to further study the plasma proteins binding rules of the major active components in single herb or Chinese medicine prescription under the guidance of holism and system biology.
The metal binding sites of the major protein were further characterized using a range of physical methods, including 113Cd NMR.
BIAcore analysis showed that the binding affinity of the major vault protein-reactive clone almost equalled that of the murine anti-major vault protein Mabs.
In this study, we used ChIP-seq to generate genome-wide profiles of the binding sites of the major adipogenic transcription factors, C/EBPα and PPARγ, in mature human SGBS adipocytes.
A key Wnt/Wg signaling mediator is the nuclear transcription factor β-catenin, which also is a binding partner of the major component of adherens junctions, E-Cadherin.
