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We show that activities of the potent bivalent inhibitors of thrombin can be reversed by the specific, but much weaker, binding of the linker moiety to protein 'antidotes'antidotes
Third, the binding of the linker histone H1 to linker DNA greatly affects chromatin folding and condensation.
The binding of the linker histone H1 further compacts the DNA into more condensed chromatin arrays [ 2].
For the CofC4_O5 ligand, additional electron density is present, probably caused by weak binding of the linker and the first DNA base.
Phosphorylation of Crk on Tyr 221 (or CrkL on Tyr 207) causes intramolecular binding of the linker region to the SH2 domain, sequestering the SH2 and SH3N and preventing them from binding target proteins [ 14, 15].
The authors' original observation – that the interdomain linker became sequestered from proteolysis concurrent with a shift to a higher molecular weight complex – led them to a model for BiP oligomerization that is based on binding of the linker of one monomer to the substrate-binding cleft of another monomer, to form a concatenated oligomer.
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Bivalent binding of the corresponding linker ("aldehyde-PEG-NHS") to adjacent NH2 groups on the tip was largely suppressed by high linker concentrations.
Especially, structural characterization of the binding of the L1 linker region to the STIL CC will be required to make further conclusions.
Interestingly, extending the staple to 27 aa compromises binding of the two linkers before the interaction recovers at the 45 aa length.
Moreover, the binding of the antigen-containing linker peptide/SL scBsDb complex is comparable to the binding of the l-l-GFP-l linker peptide/SL scBsDb complex (Fig. 7c, red graph).
These inhibitory intramolecular interactions include the binding of pYT to the SH2 domain and the binding of the SH2-kinase linker to the SH3 domain.
More suggestions(15)
binding of the outbreak
binding of the myosin
binding of the peptide
binding of the fusion
binding of the radiolabel
binding of the radioligand
binding of the heterodimer
binding of the target
binding of the ligand
binding of the karma
binding of the initiator
binding of the nation
binding of the protein
binding of the flavonoid
binding of the rabbit
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