Sentence examples for binding of the lead from inspiring English sources

Finally, we also assayed binding of the lead glycoconjugate to the putative gl precursor antibody of the PGT128 and PGT130 families20, which we expressed as membrane-bound IgM on the surface of cells to mimic Ig receptors on naive B cells and serve as a proxy for the ability of the conjugate to prime prospective naive B cells that might produce glycan-specific nAbs.

The mode of binding of the lead molecules to the RNA target was characterized by H NMR spectroscopy.

The favourable entropic component of binding of the lead series may reflect a disordered binding mode and may explain the difficulties in obtaining a crystal structure in complex with the protein.

Using a binding model of the lead and public X-ray coordinates of GLO1 enzymes complexed with glutathione analogues, we designed 4- 7-azaindole -substituted 6-phenyl-N-hydroxypyridones.

The binding conformation of the lead molecules with the hydrogen bond interactions to the Hpx domain of MMP-13 are given in Figure 3.

For example, the neutron-binding energies of the lead isotopes needed to link the energies of the four radioactive families together can be measured by determining the threshold gamma-ray energy to remove a neutron (photonuclear reaction); or the energies of incoming deuteron and outgoing proton in the reaction can be measured to provide this information.

The phosphorylation of the receptor through the binding of the ligands leads indirectly to the activation of the MAPK/ERK, AKT, and RAS/RAF pathways.

To confirm that the detected binding of the Eσx leads to transcription, we performed expression profiling with WT and rpoS knock-out strain cells under stationary phase conditions.

The preliminary crystal structure of BthTX-I chemically modified by BPB suggests that the binding of the inhibitor leads to significant structural modifications, especially in the C-terminal region [ 62].

In the functional GTPγS binding study, one of the lead molecules, -15, exhibited potent agonist activity at both D2 and D3 receptors with preferential affinity at D3.

It has been proposed that cooperative binding of Hox and Pbx/Exd proteins can lead to transactivation while binding of the individual factors leads to repression on the same promoter elements [12].