Sentence examples for binding of the highest from inspiring English sources
As the multitude of aptamers contained in a rounds library is competing for the fewer binding sites available on the relatively small number of target molecules added, the arising selection pressure leads to the preferred binding of the highest affinity oligonucleotides of the library.
An extreme case of competitive binding occurs when there is a large difference in affinity for or local abundance of the different competitors, as binding of the high-affinity or abundant partner will preclude the second partner from binding (3, 67, 68).
The binding affinity of the highest scored docked poses was calculated and correlated with experimentally measured Ki values.
This implies some restriction of diffusion and possibly binding to the high surface area of the outer biofilm.
It may be the strong binding of these high chlorinated congeners to reindeer hind's fat storages that restricts the transplacental diffusion to brown adipose of fetus.
We find that alkyl α-d-mannosides and other synthetic inhibitors of FimH confirm binding properties of the high-mannose epitope.
F-match searches against the largest library (>500) of position specific scoring matrices (PSSM) compiled on experimentally verified transcription factors binding sites of the higher eukaryotes [20], [21] from the TRANSFAC database [20].
In this work, we predict the HCII binding geometry of the high-affinity DS hexasaccharide D6 using the CVLS approach that we developed earlier.
When the binding sites of the high-affinity target genes were occupied by the specific transcription factor itself or other molecules, it would bind the low-affinity target genes and regulate the transcription of these genes.
After identifying several aptamer sequences capable of binding adenine, the highest affinity aptamers were assayed with molecules structurally similar to adenine.
