Sentence examples for binding of the growth from inspiring English sources

In this complex native environment, the efficient binding of the growth factors is determined by multivalent, specific and reversible electrostatic interactions between the sulfate groups of HSPGs and the positively charged amino acids of the growth factor.

The high-affinity binding of the growth factor receptor-bound protein 2 (Grb2) SH2 domain to tyrosine-phosphorylated cytosolic domains of receptor tyrosine kinases (RTKs) is an attractive target for therapeutic intervention in many types of cancer.

Clearly these peptides did not use any of the natural amino acid contacts required for binding of the growth factors to their receptors.

High molecular weight heparin enhances the binding of the growth factors to their receptors and thus promotes angiogenesis, while low molecular weight heparin has the opposite effect by inhibiting their binding (Yip et al. 2006; Lazo-Langner et al. 2007).

48 Transforming growth factor, beta 1 (TGFB1) signaling occurs by binding of the growth factor to transforming growth factor, beta receptor II (TGFBR2), which activates and binds to the structurally-similar TGFBR1.

Binding of the growth factor results in kinase activation and consequently in the trans-phosphorylation of the receptor, as well as of various effector molecules resulting in the stimulation of a large number of signaling cascades.

Lymphangiogenesis is mediated by binding of the lymphangiogenic growth factors vascular endothelial growth factor- (VEGF-) C and VEGF-D to their specific lymphatic receptor, VEGF receptor 3 [ 15].

For example, Cysteine-rich protein (SPARC) binds to PDGF-AB and PDGF-BB dimers, inhibiting the binding of these growth factors to their cell surface receptors [ 20] and inhibiting PDGF-induced vascular smooth muscle proliferation [ 21].

Conversely, if 1 degree tumour was transplanted into the liver, the WGA binding of the resultant growth was substantially reduced.

The up-regulation of SIRT1 expression by stretch occurs at the transcriptional level and requires the binding of the early growth response protein, EGR1 to the Sirt1 promoter.

To illustrate some of the capabilities of the NetworkViewer, we apply the tool to explore a model for the binding of the Epidermal Growth Factor Receptor (EGFR) to its binding partners.