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If true, then it could be predicted that self-compatible S-pollen protein should bind the active pocket region, thus impeding the binding of the general inhibitor.
The presence of the putative DPE element allows the binding of the general transcriptional factor, TFIID as found in most TATA-less promoter [36] [39].
The binding of SP-1/SP-3 thishis region of the promoter likely interferes with the binding of the general transcription factors.
The functional units of the core promoter are the "core promoter elements," the sequences that mediate binding of the general transcription factors to the promoter.
A similar situation was found when analyzing the data for binding of the general stress transcription factors, with none of the separate data sets including more than 6% of genes regulated by Msn2p or Msn4p.
This indicates that the main role of some transcriptional activators is to maintain promoters in a nucleosome-depleted state, which in turn indirectly allows the binding of the general transcription machinery to the core promoter.
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In all cases, only the sequences of the binding sites of the general forward and reverse primers, respectively, were missing from the final sequences due to primer trimming.
In 1996, MacCallum, Martin and Thornton used a fractal shape descriptor and showed a strong correlation of the shape of the binding region with the general nature of the antigen.
The three functional categories that included the largest fraction of cell surface proteins in hES and hSperm were both 'transmembrane transporter activity'signalnal transduction activity' and 'ion binding', and the general distribution of cell surface protein functions was similar.
This suggests that the lack of transcription is not due to a deficiency in PolII binding alone, but that prolonged TLR2 signaling also inhibits binding of other members of the general transcriptional machinery.
These findings suggest a third option methylation may repress gene expression by interfering with the binding of such general activators.
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