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Upon binding of the fourth inhibitor the dimer interface, however, becomes partially disordered.
Similar(59)
If the compounds bind the immobilized protein, the binding of the second protein will be reduced; otherwise, the binding will be largely retained.
The authors conclude a subsite binding of the second peptide unit close to the main binding pocket.
The binding of the second K+ ion also started with water dehydration at about 159 ns (Fig. 2D).
In this system, the binding of the first guest (1 2 saccharide/boronic acid complex) suppresses the rotational freedom of the two porphyrin planes, which facilitates the binding of the second guest.
Substrate activation can result from an allosteric effect due to binding of the second substrate molecule on the PAS.
Moreover, we were able to reproduce the structural changes that occur upon the binding of the third Mg2+ to the active site of the protein.
Mulliken population analysis has shown that it is only the redistribution of charges between K atom and H2 molecules which is responsible for binding of the second H2 molecule.
The results show that binding of dcAdoMet to pfSPDS stabilizes the conformation of the flexible gatekeeper loop of the enzyme and affects the conformation of the active-site amino acid residues, preparing the protein for binding of the second substrate.
All the results illustrate that binding of the third strand in either of the two orientations 5′5′3′ (JT2T4) or 5′3′3′ (JT1T3) stabilizes the underlying double-helical four-way junction and its triple-helical arms.
Positive cooperativity occurs when binding of the first substrate molecule increases the affinity of the other active sites for substrate.
More suggestions(15)
binding of the secondary
binding of the natural
binding of the catalytic
binding of the active
binding of the other
binding of the bacterial
binding of the individual
binding of the human
binding of the full
binding of the antibiotic
binding of the second
binding of the small
binding of the fatty
binding of the endogenous
binding of the extracellular
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