Sentence examples for binding of the extracellular from inspiring English sources
To determine whether Pmp23 and PBP2x interact directly in vitro and to quantify this interaction, microscale thermophoresis was carried out by titrating the binding of the extracellular domain of PBP2x31 to the full-length membrane form of Pmp23.
Here we have used plasma immersion ion implantation (PIII) treatment of polystyrene to modify the polymer surface, and so modulate the binding of the extracellular matrix protein tropoelastin.
Here we show that the binding of the extracellular domain of the TCR to pMHCI does not transmit structural changes to the pMHCI-CD8 binding site that would alter the subsequent pMHCI/CD8 interaction.
Canonical Notch signaling is initiated by the binding of the extracellular domain of the Notch receptor to Notch ligands on neighboring cells.
These effects are presumably mediated through binding of the extracellular domain of Plxdc2 to an unidentified receptor.
Notch activation begins with the binding of the extracellular domain of transmembrane ligands of the Delta and Jagged family to Notch receptors on neighbouring cells.
In vitro, the extracellular domain of Kirrel3 is capable of binding to the extracellular domain of nephrin, a type 1 transmembrane protein and member of the immunoglobulin superfamily [ 28].
These anti-GAG antibodies of RA patients were not only present in the systemic circulation and in the synovial fluid, but they were also fully capable of binding to the extracellular matrix of hyaline cartilage.
However, a key consequence of antibody binding to the extracellular domain of erbB2 appears to be enhanced removal of the receptor from the cell surface, with subsequent inhibition of receptor signalling.
This may reflect structural destabilization of ligand binding to the extracellular half of the DBS as it adopts the opened outward conformation and may be mechanistically important as a "release" state of the transporter.
Therefore, AChBPs still represent the best template for the characterization of ligand binding to the extracellular ligand-binding domain of nAChRs (Cecchini and Changeux, 2015).
