Sentence examples for binding of the existing from inspiring English sources

The rational design of new DNA binding agents requires a thorough understanding of the thermodynamics of the DNA binding of the existing drugs.

Furthermore, simultaneous occupancy of the two thyroxine binding pockets, such as the one achieved by the prototypic palindromic ligand, mds84 (Kolstoe et al, 2010), would overcome the problem of negative cooperativity of binding of the existing drugs and should improve protection against amyloidogenic misfolding of TTR.

To facilitate the discovery of clinically useful Stat3 inhibitors, computational analysis of the binding to Stat3 of the existing Stat3 dimerization disruptors and quantitative structure−activity relationships (QSAR) were pursued, by which a pharmacophore model was derived for predicting optimized Stat3 dimerization inhibitors.

In principle, there are two strategies that can be used to alter the enantioselectivity of an alkene reductase: move the substrate to the opposite side of the FMN cofactor (and provide a new general acid for α-carbon protonation) or flip the orientation of substrate binding within the existing active site.

The present algorithm predicts peptides that have better binding energies than those of the existing ones.

Existing information seems to indicate that different ETS-family members have divergent binding specificities, and no clear subgroups could be identified based on clustering of the existing binding profiles.

Lastly, the curator recorded default scores and the expected distance a binding site would be from the start of a gene based on examination of the existing binding sites.

They argued that this asymmetry arises because many mutational routes to receptor modification or loss can achieve resistance, while phage infectivity requires the evolution of specific binding to the modified version of the existing receptor or to an entirely different receptor, which is likely to be subject to greater mutational constraint.

Failure to include a binding renewable energy target would completely undo the indisputable success of the existing 2020 target in driving forward renewable energy.

The majority of the existing cheminformatics methods for predicting drug target interactions perform binary classification into binding and non-binding.

A key step in the rational design of new RNA binding small molecules necessitates a complete elucidation of the molecular aspects of the binding of existing molecules to RNA structures.