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The domain involved in the recognition and binding of the diverse aglycone substrates is purported to be located towards the N-terminal end, whereas the C-terminal region encodes a domain involved in binding the nucleotide sugar substrate [ 37].
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These results will allow the design of LSP1 mutants that do not bind to the cytoskeleton to determine the importance of LSP1 cytoskeleton binding for the diverse functions of LSP1.
Although the location of the substrate-binding site between the bundle and hash motif is similar in all of these structures, the exact binding mode of the diverse substrates varies.
Flexible docking results indicate that proper representation of the residues' flexibility is critical for reasonable description of binding of the structurally diverse inhibitors.
The Emperor viewed Catholicism as a natural way of binding the diverse principalities of the Holy Roman Empire to him.
Importantly, genetic diversity in the ABS facilitates binding of a diverse array of antigens to the molecule [ 20].
To gain a better understanding of the underlying mechanisms, we analyzed the binding of diverse chromatin proteins to the X-linked and autosomal tissue-biased genes.
These also results suggest a 3-D model of C. pugilator RXR that describes the binding of ligands at a single RXR receptor binding site and offers further insight into the binding of structurally diverse ligands to this receptor.
Ubiquitin is an important signaling molecule involved in a myriad of signaling pathways through the binding of a diverse set of receptors.
They also suggest that the binding of structurally diverse molecules induced specific ER LBD structures and/or dynamics with divergent impacts on AF-1 activity (compare BBP and chlordecone on ERβ in Figure 3A,B).
Experimental tests to empirically determine functional characteristics (e.g., PAH binding, protein-protein interactions) of the diverse AHR1 and AHR2 allelic variants would help to discern the role of SNPs in adaptation in these populations and to develop hypotheses about the role of particular haplotypes in polluted and reference populations of F. heteroclitus.
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