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Notably, the backbone of position 36, but not the sequence, is essential for binding of the core peptide to DDX3X (Figure S2)[28].
Therefore, Nanog may orchestrate transition to the pluripotent ground state by facilitating cooperative binding of the core pluripotency factors to their cognate ES cell targets.
This indicates that RNA-induced closure of M2-1 results from the simultaneous binding of the core and zinc finger domains, and that impaired binding to the zinc finger inhibits this conformational change.
This region is the specific binding site of bacterial promoters containing an extended −10-promoter element and is primarily involved in the binding of the core RNA polymerase in the holoenzyme.
The results also indicated that the CBM of N. flexuosa xylanase did not contribute to the non-productive adsorption of the enzyme on lignin but on the contrary, the CBM of N. flexuosa xylanase seemed to physically prevent the strong binding of the core protein on lignin.
Binding of the core enzyme, consists of the five core subunits—β´, β, a dimer of identical α subunits, and the ω subunit.
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However, in both cases to prevent snoRNA degradation during posttranscriptional processing, binding of the core-snoRNP proteins is essential (Richard and Kiss 2006).
It is the DNA binding element of the core binding factor (CBF) transcription complex and is required for hematopoiesis as shown in knock-out mouse studies [ 75].
The structure shows that this site is the main determinant of Lhca binding to the core.
Core binding factor (CBF) is a heterodimeric transcription factor binding to the core element of many enhancers and promoters.
Members of the annexin family differ in binding specificity of the core for phospholipid headgroups like PS, phosphatidic acid or phosphatidylinositol, as well as the binding specificity of the NH2-terminal tail.
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