Sentence examples for binding of the compounds from inspiring English sources
Our Initials studies in vitro demonstrate enhanced binding of the compounds to the sodium channel and increased inhibition of prostate cancer cell growth in culture and in soft agarose compared with phenytoin.
Kinetic measurements with pea (Pisum sativum) diamine oxidase and oat (Avena sativa) polyamine oxidase demonstrated reversible binding of the compounds at the active sites of the enzymes as they were almost exclusively competitive inhibitors with Ki values ranging from 10−5 to 10−3 M.
This was further supported by docking into a homology model of the α4-β2 nAChR interface and by surface plasmon resonance biosensor analysis of binding of the compounds to acetylcholine-binding proteins, where they exhibit preference for Lymnaea stagnalis ACh binding protein (Ls-AChBP) over the Aplysia california ACh binding protein (Ac-AChBP).
To explore the relative binding of the compounds in living cells, we performed FRET studies in U2OS cells.
This assay was used to measure the binding of the compounds to sGCcat.
The bioaffinity traces with increasing peak maxima correspond to the dose-dependent increases in binding of the compounds to the receptor.
However, the structural effects of the binding of these compounds with the enzyme active site are not completely understood.
This may indicate that further protein targets are mechanistically relevant, or that binding of the compound directly to the lipid is a possible mechanism.
Target specificity of the lead compound was established by demonstrating direct binding of the compound to Magmas and by genetic studies.
These were classified into different indications by manually inspecting all database entries (we define indication as a certain symptom which could be treated by the compound rather than the binding of the compound to a certain target).
