Sentence examples for binding of the catalytic from inspiring English sources

The structure is suggestive of the repositioning, during substrate binding, of the catalytic water for activation and subsequent nucleophilic attack.

PCSK9 is thought to accelerate the degradation of hepatic low density lipoprotein receptor (LDLR) [3] [5] in endosomes/lysosomes [6] by direct binding of the catalytic subunit of PCSK9 to the EGF-A domain of the LDLR [7], [8].

Mismatches within the miRNA's seed directly impair binding of the catalytic miRNA-Argonaute complex to its target sequence much more than mismatches in the 3′-supplementary region.

These conformational adjustments facilitate binding of the catalytic magnesium necessary to activate the primer 3′-OH and position the α-phosphate of the incoming dNTP.

These enzymes are typically composed of a catalytic domain and a carbohydrate binding module (CBM) that targets binding of the catalytic domain to a specific substrate [ 37].

Integrator has been shown to bind snRNA loci, and as expected, HIT-Seq detected Integrator — as defined by the binding of the catalytic core of both INTS9 and INTS11 — at snRNA genes.

The effect of guest binding on the catalytic behavior of [ 4AuCl] is noteworthy on a number of counts.

Each step starts with displacement of protein binding to the catalytic centre to allow binding of another set of proteins to promote the catalytic reaction.

The stoichiometry of omeprazole and pantoprazole binding to the catalytic subunit of the H+,K+-ATPase was 2 moles of inhibitor per mole of the H+,K+-ATPase phosphoenzyme.

Conceivably, the removal of factors binding to the catalytic centre and functioning in the previous step converts the catalytic centre into an open state, allowing splice sites to interact in a dynamic manner.

In the established experimental system, the neutralization of TIMP-2 with purified IgG interfered with TIMP-2 binding to the catalytic domain of MMP9.