Sentence examples for binding of the bivalent from inspiring English sources
If this is indeed true, then the actual binding of the bivalent IgG POM2 and POM12 will be the result of this cooperative interaction.
The actual binding of the bivalent IgG POM2, however, is a result of the cooperative interaction of each paratope of the IgG molecule with two – either consecutive or intermittent – epitope stretches within the octarepeat region of PrP.
This was probably due to the fact that the reaction stoichiometry became increasingly complex, since we tested the binding of the bivalent IgG (POM2 or POM12) antibody to the tetravalent rmPrP23-231 – since the POM2 and POM12 epitope occurs four times in the PrP sequence.
The binding of the bivalent ligand induces dimerization and activation of PDGFRs, leading to autophosphorylation of tyrosine residues in the intracellular region [ 2].
Did this negatively charged sequence act as a barrier to receptor activation which could be overcome by binding of the bivalent cytokine ligand?
Binding of the bivalent ligand reorientates and rotates the receptor subunits, resulting in a transition from a form with parallel TMDs to one where the TMDs separate at the point of entry into the cytoplasm.
Driven by the binding specificities of the bivalent, epidermal growth factor (EGF -related pEGF -relatedds and the compeptide of receptors availigandsn the cell, ErbB receptors form different homodimeric and hetheodimericomplements (see review by Gullick [ 2]).
The model derived from these experimental and in silico findings predicts that binding of a bivalent ligand to the GH receptor will bring the ECD site 3 structures into proximity and then association through subunit rotation, and this will facilitate closer apposition of the upper JM sequence by overcoming the electrostatic repulsion of the JM EED sequence.
We showed that the bivalent binding of the diabody antibody constructs leads to agglutination of S. mutans.
He has now found that these transcription factors bind at many of the bivalent domains created by the polycomb complex.
The binding kinetics of the mAb (bivalent antibody) and scFv (monovalent scFv) for this antigen was analyzed along with an assessment of the thermodynamics of the binding interactions.
