Sentence examples for binding of the androgen from inspiring English sources

Previous data have shown that the level of PCA3 can be induced in LNCaP cells after treatment with dihydrotestosterone, which mimics the effects of binding of the androgen receptor (DHT) [16].

We found that androgen can activate CEBPD transcription by direct binding of the androgen receptor (AR) to the CEBPD promoter region.

Production of PSA is mediated through binding of the androgen receptor (AR) to androgen response elements (ARE) in the promoter region of the PSA gene (Janne et al, 1993).

ChIP assays were performed as described in the literature [ 56- 58], and specific PCR primers were designed to detect binding of the androgen receptor to the putative ARE promoter sequence of asMYO5A, identified by in silico analysis.

Several mechanisms have been proposed to explain DES activity, including reduction of luteinizing hormone, testosterone and androgenic steroid levels (Bosset et al, 2012), inhibition of telomerase activity (Geier et al, 2010); direct binding of the androgen receptor (AR) (Wang et al, 2010) and suppression of β-tubulin isotypes (Montgomery et al, 2005).

Binding of the androgen receptor to a putative regulatory region upstream from asMYO5A, an androgen-regulated antisense intronic transcript, was confirmed by chromatin immunoprecipitation.

Two well-studied human tandem-repeat polymorphisms are situated within the X-linked androgen receptor (AR) gene, which codes for a transcription factor that mediates binding of the androgens testosterone (T) and dihydrotestosterone.

Identification of several environmental chemicals capable of binding to the androgen receptor (AR) and interfering with its normal function has heightened concern about adverse effects across a broad spectrum of environmental chemicals.

Androgens stimulate and control the development and maintenance of masculine characteristics by binding to the androgen receptor (AR) and inducing a cascade of hormone responses.

15 16 Action of testosterone through binding to the androgen receptor in the developing fetal brain is the predominant factor in programming human male gender identity, 7 17 and the female gender identity of 46,XY cAIS women is explained by loss of this androgenic effect.

More recently it has been observed that this drug is active in CRPC (Farrugia et al, 2000), the mechanism of this may include binding to the androgen receptor.