Sentence examples for binding of the activating from inspiring English sources

Asp26 (homologous to Gly12 of p21ras) was essential for the binding of the activating nucleotide, guanosine 5'-3-O- thio triphosphate.

This observation suggests that HDL inhibit IL-1β production by interfering with the binding of the activating factor to its receptor on monocytes.

Therefore, HDL may inhibit cytokine production in human monocytes by interfering with the binding of the activating factor(s) at the surface of stimulated T cells to receptor(s) at the surface of monocytes.

This motif is characteristic of many cdks and is central to the binding of the activating cyclin subunit to the kinase [4].

Although the increased binding to the inhibitory CD32B receptor could limit toxicity, it is compensated by the enhanced binding of the activating receptors, which is greater than that observed with human orthologs.

Among the top ten discovered motifs we found four binding motifs of the activating E2F family transcription factors, E2F2 and E2F3, with p-values < 10-80 (see Figure 5C).

Whereas MtbPRPPase exhibited a more stable conformation in the presence of Mg-ATP (t1/2, >2hrs versus 10'20″ of the enzyme in the absence of ligands), the presence of free Mg2+ ions did not lead to any increased protein stability (t1/2, 11'40″), suggesting that the binding of the free activating ion did not induce large rearrangements of the protein.

In the post-implantation embryo, following the binding of transcriptional activators, activating loops form on the maternal chromosome between enhancers and the promoters of Slc22a2 and Slc22a3, causing their upregulation.

Response to trastuzumab in metastatic breast cancer correlates with expression of the high binding variant (158V) of the activating Fcγ receptor IIIA (CD16A).

Nutlins bind to the p53-binding pocket in the MDM2 protein, thus inhibiting the binding of p53 and activating the p53 pathway in cancer cells with wild-type p53, including solid tumors [10], [11] and hematological malignancies [12], [13], [14], [15].

RAGE ligands therefore have better binding across to cell membrane receptor, the binding of which activates the inflammatory pathways.