Sentence examples for binding of the activated from inspiring English sources
Unfortunately, subsequent tests with OAS-activated CysR led to the finding of an indiscriminate binding of the activated protein to DNA in vitro: activated CysR binds as well to Cy3-labelled negative controls (e.g., to an internal fragment of cg2118 [ 28]; Fig. 3B) as to unlabelled blocking DNA (Fig. 3C).
We found that disruption of the link between Shank3 and the Homer-mGluR1a/mGluR5, but not GKAP/PSD-95/NMDA-R complex, allows direct binding of the activated Gbetagamma subunits to the NMDA channel, upon concomitant activation of the group-I mGluRs, and rapid inhibition of the channel.
Notch pathway activity is transmitted to target genes by binding of the activated Notch intracellular domain (NICD) to the CBF1/Suppressor of Hairless/LAG-1 (CSL) DNA-binding protein.
DNA binding of the activated androgen receptor organizes a cascade of events in the nucleus, leading to transcription and translation of a specific network of genes that is responsible for the cellular response to the steroid.
These iDREs either overlap or are immediately adjacent to response elements, so binding of the activated AHR complex blocks binding of other transcription factors, preventing transcription [ 94– 94].
The effects of 1,25(OH)2D are mediated by complex nuclear receptor and the binding of the activated complex to regulatory DNA sequences of target genes.
This observation suggests that HDL inhibit IL-1β production by interfering with the binding of the activating factor to its receptor on monocytes.
Therefore, HDL may inhibit cytokine production in human monocytes by interfering with the binding of the activating factor(s) at the surface of stimulated T cells to receptor(s) at the surface of monocytes.
Although the increased binding to the inhibitory CD32B receptor could limit toxicity, it is compensated by the enhanced binding of the activating receptors, which is greater than that observed with human orthologs.
In the post-implantation embryo, following the binding of transcriptional activators, activating loops form on the maternal chromosome between enhancers and the promoters of Slc22a2 and Slc22a3, causing their upregulation.
