Our results clarified that the parameter A Ф · AUCФ, in which the receptor binding occupancy of the action target, the 5-HT1B/1D receptor, and occupancy rate were taken into account, was a good index for quantitatively evaluating clinical efficacy without regard to dosage form.
Phosphorylation of ERα is enhanced in response to estrogen binding and through the action of second messenger signaling pathway [ 32].
Besides, the protective effect of phosphatidylcholine against proteolysis of native β-lg could be due to the binding of the lipid that blocks the action of proteases for steric reasons (Mandalari et al. 2009).
IGF-1 binding proteins inhibit the action of local IGF-1 in a spatial and temporal manner [ 40, 49].
EDTA or other chelating agents are frequently added in the first decellularization steps to disrupt cell-cell binding and potentiate the action of the following treatments [ 42].
Methylene blue (MB) exerts an antioxidant effect by binding and inactivating the action of NO [ 44], blocking the soluble guanylate cyclase [ 45] - the primary receptor for NO - as well as inhibiting Nitric Oxide Synthase (NOS) [ 46].
Patients showed increased binding of the perceived time of actions towards their effects.
This binding of subjective action time by a subsequent stimulus depends on learning the underlying contingency (Moore, Lagnado, Deal, & Haggard, 2009; Walsh & Haggard, 2013).
Action binding results from a cue integration of the action and sensory effect, whereby the action and its effect provide two separate cues for estimating the time of action (Wolpe et al., 2013).
