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In order to generate sufficient signal, non-isotopic ISH methods usually use long probes or multiple probe cocktails for binding of sufficient number of label molecules to each target.
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The Fc receptors on macrophages and dendritic cells bind to the constant region of antibody and the binding of a sufficient cluster of Fc receptors activates actin mediated uptake of the microorganism.
These data are in full agreement with work of Deng et al. who showed that binding of Jak2 is sufficient to inhibit GHR down-regulation [24].
Removal of the IL from the allosteric site, either by mutation [ 8] or binding of substrate is sufficient to allow active site formation.
This structure, along with previously reported structures, increases our understanding of the RebC enzyme mechanism, indicating that either the reduction of the flavin itself or binding of substrate is sufficient to drive major conformational changes in RebC to generate a closed active site.
Taking advantages of sufficient binding sites of the GO with oxygen-containing groups, the enzymes (GOD) are covalently immobilized onto GO-deposited TFG via 1-ethyl-3- 3-dimethylaminopropyl) carbodiimide and N-hydroxyl succinimide cross-liner.
We believe, however, that we have shown that the lack of NEDD4L binding is sufficient to explain the lack of function of AMOT p80.
As yet there are no cytoplasmic proteins of sufficient PI5P binding specificity to be classed as convincing PI5P effectors, especially given the relatively higher levels of PI3P and (especially) PI4P in cells (see, e.g. (Roberts et al., 2005)).
Overall, a common oncogenomic program driven by binding of either Notch is sufficient to maintain T-ALL cell growth, whereas cell-context specific differences appear to influence the response of T-ALL cells to Notch inhibition.
This allows sufficient binding of the bacteria to its predicted targets.
Sufficient binding of BoNT to the bead-bound antibodies requires 3 hrs at 25°C and just 1 hr at 37°C.
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