Sentence examples for binding of substrate in from inspiring English sources

Thus, while Compound 1 closely mimics the binding of substrate in the FtDHPS module, it only partially mimics substrate binding in the FtHPPK module.

This allosteric mechanism is triggered by the binding of substrate in the S2 site in the presence of the substrate in the S1 site.

In the movement of substrate from S1 to the intracellular side, these structural elements perform an ordered sequence of local rearrangements that are triggered by the binding of substrate in the S2 site.

The precise reason for this observed biphasic kinetics for fatty acid cannot be discerned at present, although, several plausible reasons for such kinetic behavior could involve the presence of multiple substrate binding sites with different binding affinities or binding of substrate in more than one orientation with different affinities [44], [45].

The equilibrium between the apo-caspase (inactive) and the mature caspase is modulated by binding of substrate in the active site or by binding of inhibitors in allosteric sites.

The hydrophobic cleft was found to be essential for the recognition and binding of substrate proteins as mutations within this region were lethal in vivo and prevented binding of substrates in vitro.

The activation of Ugd depends on phosphorylation of a specific tyrosine residue which in its nonphosphorylated form hinders the binding of substrates in the active site (Petranovic et al. 2009).

The binding position of substrate in the active site was determined but interaction between the substrate and Ser-464 or Leu-465 was not observed, although amino acid residues at these two positions are the only structural distinctions between wheat and rye glucosidase catalytic pockets.

We also demonstrate (Fig. 3C) that while the mAb Wh-2-11-1 Wh-2-11-1 Wh-2-11-1 Wh-2-11-1ty on the binding of showsrane (VWF) increase transfected winh reactivity an antibony thethe V5 tag on rADAMTS13 (which is not sensitive to the conformation of the epitope) shows negligibindingnge.

Moreover, a channel created to the heme pocket by removal of the native His64 gate (His64 to Ala64 mutation) was shown to facilitate the binding of substrate, resulting in enhanced catalytic efficiency for the triple mutant L29H/F43H/H64A Mb, which is beyond the addition of both double mutants, L29H/H64A Mb and F43H/H64A Mb.

Taken together, these studies clearly showed a rearrangement of the subunits around the quinone binding pocket after the binding of substrate and inhibitors in the bacterial and mammalian enzyme.