Sentence examples for binding of specific tRNAs from inspiring English sources

Unique triplets promoted the binding of specific tRNAs to the ribosome.

Recent work has shown that a conformational switch to form a tRNA aptamer is at the heart of the mitochondrial import of specific tRNAs by enolase-preMSK1 [11].

12 However, downregulating the abundance of specific tRNA species in the cell in order to selectively inhibit viral protein synthesis can be done by interfering any of the processes occurring in the tRNA life-cycle, and not only by binding to the aminoacylated tRNA molecule.

Translation in yeast starts by the formation of the PIC (pre-initiation complex) which is formed in three steps: first, binding of the specific initiation Met-tRNA to the small ribosomal subunit; second, the resulting complex binds to the mRNA molecules localizing the start codon; and third, the attachment of large ribosomal subunit to generate the polysome structure.

Indeed, lack of a specific tRNA modification has been shown to increase tRNA half generation [ 41].

Our rigorous calculations demonstrate that the A1492/3 flipping is indeed a specific response to the binding of cognate tRNA, contributing 3kcal/mol to the specificity of tRNA selection.

In contrast to this functional divergence, convergence of function is also seen in the superfamily, specifically concerning binding of tRNA, and structural mimics of tRNA.

Our results are consequently in good agreement with the common idea that specific noncanonical bases fine-tune the binding of tRNAs to the ribosome.

Interestingly, we found that the majority of Hmt1 occupancy at tDNAs did not follow an all or none trend when we examined the binding of Hmt1 to the entire set of alleles for a specific tRNA gene species.

Furthermore, the addition of up to 80 μg of non-specific tRNA per binding reaction had no effect on binding at 20 °C (Supplementary Figure S4 at http://www.BiochemJ.org/bj/434/bj4340427add.htm), suggesting that the interaction is highly specific.

By partially inducing these structural changes, paromomycin facilitates binding of near-cognate tRNAs.