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Subsequent binding of specific protein factors, Yju2/Cwc25 for the first step and Slu7/Prp18/Prp22 for the second step, facilitates and confines the interaction at specific sites.
The NHEJ process is initiated by the binding of specific protein to the broken ends, which may act as end bridging factor [ 214].
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Researchers have found that a part of the cell nucleus called the nuclear matrix — containing up to about 10percentt of the total protein in the nucleus — is extremely sensitive to heat, which causes changes in the binding of specific proteins to the matrix.
Such ARE have been noted to regulate mRNA at the post-transcriptional level, mostly through binding of specific proteins [34].
The binding of specific proteins to cognate mRNA sequences and formation of translocationally-competent nucleoprotein complexes enables the intracellular trafficking of mRNA molecules.
For the genome-wide analysis, we relied on data from the ChIP-Seq experiments that use high-throughput sequencing to map the binding of specific proteins or chromatin modifications across the genome [9], [10].
Phosphorylation or dephosphorylation of specific residues favours binding of specific proteins.
Histones are subject to a slew of PTMs that regulate the binding of specific proteins.
We can propose several layers of regulation: (1) Phosphorylation or dephosphorylation of specific residues favours binding of specific proteins.
Does the bias determinant communicate with the ARS through the binding of specific proteins to the bias determinant?
Coding region polymorphisms may also underlie haplotype-specific copy-number regulation (Suissa et al. 2009), for example, by influencing the binding of specific proteins.
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