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The transport of pigment organelles during aggregation and dispersion is regulated by signaling mechanisms initiated by the binding of specific hormones to cell surface receptors, which results in the modulation of cAMP concentrations [4], [5].
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These properties include selective action, either in specifically binding to a receptor orthologue, isoform, or subtype; the selective activation of specific hormone response elements; or antagonism, where a ligand competes with the natural hormone for binding to the receptor but does not activate it.
Different environmental pollutants act as hormone mimics, binding to specific hormone receptors or indirectly interfering with hormone signaling.
Nuclear hormone receptors are ligand-activated transcription factors that modulate gene expression through binding to specific hormone response elements.
PPARgamma belongs to the nuclear hormone receptor family of transcription factors, which are activated upon binding of specific ligands or agonists.
The C-terminal portion of the receptor includes the ligand binding domain which recognizes specific hormones, vitamins, retinoids or other lipophilic compounds.
Intracellular and intranuclear actions of hormones belonging to these classes are mediated through binding of the hormones to specific receptors.
Similar molecular reactivities are supported by the demonstration of effective specific binding of thyroid hormones and chlorinated aromatic hydrocarbons with four different proteins, enzymes, or receptor preparations that are known or suspected to be involved in the expression of thyroid hormone activity.
Adipose cells also express receptors capable of binding specific steroid hormones that can signal for increased storage of fat or increased release of fatty acids.
Hormonal action requires the binding of the hormone to specific receptors (Zouboulis 2000).
Demay M, Mitchell J, Goltzman D. Comparison of renal and osseous binding of parathyroid hormone and hormonal fragments.
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