Sentence examples for binding of specific cofactors from inspiring English sources

Many proteins in nature necessitate the binding of specific cofactors to perform their biological function.

Our analysis suggests that the functionality of binding is highly condition-specific and highly dependent on the presence of specific cofactors.

Additionally, the availability of specific cofactors may also influence this regulation.

This analysis reveals that functionality is mainly determined by the presence of specific cofactors.

The activation of these caspases requires binding to specific cofactors, caspases possess different domains, containing death-effector domains (DED) or caspase recruitment domains (CARD) [ 30] and we also observed a down-regulation in some of these cofactors, specifically with Apaf-1, CARD8, NOD1, NOL3, RIPK2 and DAPK1, in OP bone.

The VCP dislocase serves as the "motor" that mediates those cellular functions by binding to specific cofactors including Ufd1, Npl4, and p47.

172– 175; and (3) ChIP-seq on TFs or cofactors (p300, CEBPB, etc).. 176 However, the mapping of open chromatins and histone modifications usually lacks sufficient resolution and specificity to detect precise enhancer locations, and the binding of some specific TFs or cofactors can hardly cover all the active enhancers.

Current models suggest that the binding of P300/CBP cofactors to transcription factor activation domains positions histone acetyltransferases near specific nucleosomes in the promoter regions of the target gene.

Full activation of both Auroras requires binding to specific protein cofactors.

VCP forms homohexamers, and N-terminal domain (N-domain) binding of various cofactors plays a role in the multi-functionality of the protein, enabling it to target specific substrates for degradation via the ubiquitin proteasome system.

The binding of H4B cofactors was detected by the initial difference Fourier maps calculated with REFMAC.