The activity of PPARγ can be modulated by the direct binding of small molecules — thiazolidinediones.
The study of binding of small molecules with supramolecular architecture comprises of one of the thriving areas of research today.
Induced-fit effects are well known in the binding of small molecules to proteins and other macromolecular targets.
Mass spectrometry (MS) is widely used to assess the binding of small molecules to proteins and their complexes.
This family of hexameric proteins may provide a useful framework for the construction of proteins that change their oligomeric states in response to binding of small molecules.
Footprinting is a method that has been developed for determining the sequence-specific binding of small molecules, oligonucleotides, or proteins to DNA.
Central cellular functions such as metabolism, solute transport and signal transduction are regulated, in part, via binding of small molecules by specialized domains.
The binding of small molecules to double stranded DNA including intercalation between base pairs has been a topic of research for over 40 years.
From combined analysis of MD data and paramagnetic profiles, two CXCL12 sites suitable for the binding of small molecules were identified.
These regulatory mechanisms are still being defined, but various principles can be distinguished such as a requirement for homodimerization (e.g. RNF4, BIRC7, XIAP, and IDOL 5,12,13,14, heterodimerization (e.g. in Mdm2-MdmX, BRCA1-BARD1, RING1B-Bmi1)15,16,17,18, or the binding of small molecules (sphingosine-1-phosphate binding to TRAF219 or PAR binding to RNF146 20.
