Sentence examples for binding of small RNAs from inspiring English sources
Hfq is a RNA chaperon which mediates the binding of small RNAs to the mRNA and assists in post-transcriptional gene regulation in bacteria.
Binding of small RNAs to the target sequence may result in degradation or translation inhibition of the target.
The manuscript by Dickerman et al. describes an attempt to study the functional conservation of RNA binding proteins implicated in processing of small RNAs and activation of dsRNA-dependent protein kinase (PKR).
The level of the RUFs was examined in cells silenced for the C/D and H/ACA core proteins as described above, and in cells depleted for Lsm8 and SmD1, and their levels were unchanged, suggesting that these are novel small RNAs, not belonging to known classes of small RNAs, and have binding proteins that are yet to be discovered.
The PAZ domain is a key region that interacts with the 3' end of small RNAs and determines the RNA-binding specificity of Argonautes.
The RNAs that do not belong to the previously described most abundant families of small RNAs, such as C/D and H/ACA snoRNAs or RNAs binding the Sm or Lsm proteins, were termed RNAs of Unknown Function (RUFs).
In plants and animals, a large number of double-stranded RNA binding proteins (DRBs) have been shown to act as non-catalytic cofactors of DICERs and to participate in the biogenesis of small RNAs involved in RNA silencing.
The resolution of Ago-associated small RNAs showed a significant landscape of Ago proteins and their binding to small RNAs [ 18, 19, 21, 48- 50].
In recent years, it was found that nucleus localization of AGO4 could be determined by binding to small RNAs [ 24].
The presence of AGO1 in the RNA Pol II (8WG16) pulldown fraction indicates that AGO1 might have an affinity for binding to small RNAs arising from heterochromatin.
The binding of a class of small RNA molecules, microRNAs (miRNAs), to mRNA transcript targets has recently been demonstrated to be an important mechanism of gene regulation.
