Sentence examples for binding of regulatory elements from inspiring English sources

As the G4C2 repeat is located between two transcription initiation sites, C9orf72 expression might be disrupted by aberrant binding of regulatory elements or altered methylation.

The rs4586C/T polymorphism is a synonymous marker, whereas the two other SNPs are located into the 3′ region of the gene and may affect stability of the transcript or the binding of regulatory elements.

For the TIRAP gene, only one marker, located into the 3′UTR region of the gene, was strongly associated (rs8177376A/C) and may affect stability of the transcript or the binding of regulatory elements.

Although these SNPs were not studied before, is in line with the literature in studies performed in other Latin American countries with diverse ethnic compositions, where several SNPs were located in the 5′UTR of the CCR5 gene where they may influence binding of regulatory elements to gene expression control regions [ 22, 47, 48, 61].

The role, if any, of these SNPs in binding sites of regulatory elements remains to be studied.

Therefore, it is reasonable to speculate that the COX-2.8473 polymorphism, located downstream of the stop codon in the adenylate/uridylate-rich 3'-UTR region [ 20], could partly decrease mRNA stability and expression either by modifying the efficiency of polyadenylation signals or by affecting the binding affinity of regulatory elements.

In these studies, however, HNF4A inactivation occurred between P35 and P40, while using our mice (carrying a different Alb-Cre transgene) TAF4 inactivation is complete by P12 resulting in the loss of HNF4A binding to regulatory elements of at least 296 genes.

In plants, conserved noncoding sequences have been first identified in the grasses [ 5- 7], and evidence of regulatory elements or binding sites in these noncoding sequences has been obtained [ 6, 7].

At last, IκBNS drives the development of regulatory T cells by binding to regulatory elements of the Foxp3 locus, whereby IκBNS-deficient mice display reduced Treg numbers [ 80].

Therefore, we investigated the level of PU.1 binding to regulatory elements in known PU.1 target genes (PU.1/Sfpi1, IRF8, and Flt3).

In addition, our ChIP-seq data suggests that SMARCE1 may regulate EGFR expression through direct binding to regulatory elements of EGFR locus.