Sentence examples for binding of par from inspiring English sources

A second proposed mechanism of recruitment is via binding of PAR chains, which are deposited on chromatin at sites of DNA damage by PARP proteins.

The interaction of Lgl with PAR-6 and aPKC precludes the binding of PAR-3 to PAR-6 and aPKC.

In the neuroblast, for example, Baz acts an aPKC targeting factor by recruiting the PAR-6/aPKC complex to the cortex through the binding of PAR-6 and serves as an aPKC specificity determinant by recruiting Numb to the Baz/PAR-6/aPKC complex, so that aPKC can phosphorylate it (Wirtz-Peitz et al., 2008).

Similarly, the in-silico docking and molecular dynamics simulation clearly explain the theoretical basis of the binding mechanism of PAR with HSA.

The finding of present investigation will provide binding insight of PAR and associated alterations in the stability and conformation of HSA.

Similarly, the binding of mammalian PAR-3 to PKCζ in a pulldown assay is blocked when the equivalent serine is mutated to the phosphomimetic glutamate (Nagai-Tamai et al., 2002).

The isolated Tiam1/2-binding region of Par-3 (the rat 4N/1 fragment, residues 937 1038) has been shown to be sufficient to increase the amount of Rac1-GTP for induction of lamellipodia by binding to Tiam1 (Nishimura et al, 2005).

The binding of CagA to PAR-1 blocks the kinase activity of PAR-1 thus preventing the phosphorylation of PAR-3; at the same time, it prevents the phosphorylation of itself by aPKC.

Jeng et al. [ 53] have shown that the binding of thrombin and PAR-1 induces rapid calcium mobilization and increase of [Ca2+]i, with [Ca2+]i peaking at 30-40 s followed by a rapid drop.

The biochemical feature of binding PAR is required for macro domain proteins including LRP16 to participate into PARP-1-based PARP-1-based PARP-1-basedA damage [19], [20].

If Crb blocks the apical localization of Baz by preventing its binding to PAR-6, a construct in which Baz is constitutively associated with PAR-6 should phenocopy BazS980A.