Thus, SoxS is a global regulator that modulates the expression of other regulators.
The distortion of DNA by the HMG-box is primarily mediated through contacts with the minor groove of the DNA helix, potentially allowing simultaneous binding of other transcriptional regulators to the DNA [ 8, 9].
U2AF65's degenerate specificity also opens the possibility of competitive binding with other regulators at defined subsets of sites.
Although the putative DNA-binding motifs of NdgR and its orthologs were previously predicted using the known binding sequences of other IclR-type regulators in different strains [ 15- 18], clear consensus sequences remain undefined.
In view of these data, we postulate that CCN6 may modulate the availability of IGF-1 to the IGF-1R, conceivably by binding and sequestering IGF-1, and/or by interfering with other regulators of the IGF signaling pathway.
Many gave up the supervision of banks to other regulators.
Response regulators may modify genes expression by direct binding to the genes promoters or by action on other regulators that, in turn regulate target genes expression [16], [33] [36].
NPM enhances p53 activity directly by binding to and stabilizing p53 or indirectly by stimulating the induction of p53 through binding to other p53 regulators, such as HDM2 and ARF [ 118– 118].
The combinatorial binding of haematopoietic regulators such as RUNX1, SCL/TAL1 and FLI1 and others specifies cis-regulatory elements active in haematopoietic cells (Wilson et al, 2010).
Additionally, two co-regulators may fail the independence test even if one of the co-regulators is an insignificant regulator, owing to the strength of the other regulator.
